{"id":860307,"date":"2022-04-25T07:00:37","date_gmt":"2022-04-25T11:00:37","guid":{"rendered":"https:\/\/www.thecompliancecenter.com\/ca\/?p=860307"},"modified":"2025-09-08T01:34:35","modified_gmt":"2025-09-08T05:34:35","slug":"ate-calculations","status":"publish","type":"post","link":"https:\/\/www.thecompliancecenter.com\/ca\/help-center\/articles\/ate-calculations\/","title":{"rendered":"ATE Calculations"},"content":{"rendered":"

\"\"<\/p>\n

ATE or Acute Toxicity Estimate is a calculation needed when authoring a Safety Data Sheet (SDS) for an untested mixture. Let\u2019s face it, most mixtures are untested.<\/span>\u00a0<\/span><\/p>\n

What do you need to do?<\/span>\u00a0<\/span><\/p>\n

First, gather the oral and dermal LD50 values, then gather the inhalation (dust, mist, and vapor) LC50 values for each relevant ingredient in the mixture. Make sure the data is reliable and has been done with the correct species (rat or rabbit) and to the correct time period\/test procedure. When doing ATE calculations, you must include Acute Toxicity values for category 5, even though OSHA does not include that as one of their building blocks.<\/span>\u00a0<\/span><\/p>\n

Once you have all of the data, then you can do the calculation for each route of entry. From OSHA Hazcom Appendix A for Health Hazards, here is the equation:<\/span>\u00a0<\/span><\/p>\n

\"\"<\/span><\/p>\n

Looks scary, doesn\u2019t it? Once you put real numbers to it, it is just math (yep, scary).<\/span>\u00a0<\/span><\/p>\n

Let\u2019s look at an example:<\/span>\u00a0<\/span><\/p>\n

Ingredient A<\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Ingredient B<\/span>\u00a0<\/span><\/p>\n

60%: 4000 mg\/kg\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a040%: 1870 mg\/kg<\/span>\u00a0<\/span><\/p>\n

Divide the concentration into the LD50 value<\/span>\u00a0<\/span><\/p>\n

60\/4000=0.015<\/span>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a040\/1870=0.021139037<\/span>\u00a0<\/span><\/p>\n

Next, add the two results together<\/span>\u00a0<\/span><\/p>\n

0.021139037 + 0.015 = 0.0361<\/span>\u00a0<\/span><\/p>\n

Finally divide 100 into the result.<\/span>\u00a0<\/span><\/p>\n

100\/0.0361 = <\/span>2770.08 Acute Toxicity Category 5 (oral)<\/span><\/b>\u00a0<\/span><\/p>\n

Note that the equation is different if you have >10% unknown toxicity. That equation I will keep as a secret for now, lol.<\/span>\u00a0<\/span><\/p>\n

Need help with your calculations? Give us a call, our Regulatory Experts are here to help.<\/span>\u00a0<\/span><\/p>\n

Stay up to date and sign up for our newsletter!<\/span><\/a><\/p>\n

We have all the products, services and training you need to ensure your staff is properly trained and informed.<\/strong><\/em><\/p>\n\n\n\n
\"\"<\/a><\/p>\n

Safety Data Sheet (SDS) Services<\/a><\/td>\n

\"GHS<\/a>
\nOSHA \/ WHMIS \/ GHS Training Courses<\/a><\/td>\n		\"\"<\/a>
\nGHS (Workplace) Posters & Charts<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

ATE or Acute Toxicity Estimate is a calculation needed when authoring a Safety Data Sheet (SDS) for an untested mixture….<\/p>\n","protected":false},"author":12549,"featured_media":860309,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"categories":[2402,4037,4870,5072,5080,5081,5091],"tags":[2362,2364,2429,2443,2502,2525,2531,2574,2636,2648,3003],"class_list":["post-860307","post","type-post","status-publish","format-standard","has-post-thumbnail","category-safety-2","category-compliance-training","category-osha-whmis-clp","category-workplace-safety","category-osha","category-whmis","category-sds-workplace","tag-dangerous-goods","tag-hazmat","tag-regulations","tag-safety","tag-ghs","tag-sds","tag-osha","tag-hazardous-materials","tag-workplace-safety","tag-hazcom","tag-whmis"],"acf":[],"yoast_head":"\nATE Calculations | ICC Compliance Center<\/title>\n<meta name=\"description\" content=\"Wondering how to do ATE Calculations? 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